Bookedited by Mark S. LeDoux.
Contents:
Section I: Scientific foundations. Taxonomy and clinical features of movement disorders
Modeling disorders of movement
New transgenic technologies
Assessment of movement disorders in rodents
Drosophila
Use of Caenorhabditis elegans to model human movement disorders
Zebrafish
Techniques for motor assessment in rodents
Induced pluripotent stem cells (iPSCs) to study and treat movement disorders
Neurophysiologic assessment of movement disorders in humans
Neurophysiological and optogenetic assessment of brain networks involved in motor control
Functional imaging to study movement disorders
Human and nonhuman primate neurophysiology to understand the pathophysiology of movement disorders
Section II: Parkinson disease. The phenotypic spectrum of Parkinson disease
genetics and molecular biology of Parkinson disease
Genotype-phenotype correlations in Parkinson Disease
From man to mouse: the MPTP model of Parkinson disease
Rodent models of autosomal dominant Parkinson disease
Rodent models of autosomal recessive Parkinson disease
Drosophila models of Parkinson Disease
Primate models of complications related to Parkinson disease treatment
Rodent models of treatment-related complications in Parkinson disease
Methods and models of the nonmotor symptoms of Parkinson disease
Section III: Dystonia. Dystonia: phenotypes and genetics
Murine models of caytaxin deficiency
Animal models of focal dystonia
Mouse models of dystonia
Rodent models of autosomal dominant primary dystonia
Modeling dystonia-parkinsonism
Section IV: Huntington disease. Genetics of Huntington disease (HD), HD-like disorders, and other choreiform disorders
Murine models of HD
Use of genetically engineered mice to study the biology of huntingtin
Modeling Huntington disease in yeast and invertebrates
HDL2 mouse
Analysis of nonmotor features in murine models of Huntington Disease
Section V: Tremor. Essential tremor
Use of the harmaline and [alpha]1 knockout models to identify molecular targets for essential tremor
Physiological and behavioral assessment of tremor in rodents
Mouse models of the fragile X tremor/ataxia syndrome (FXTAS) and the fragile X premutation
Section VI: Myoclonus. Myoclonus: Classification, Clinical Features, and Genetics
Mouse model of Unverricht-Lundborg disease
Post-hypoxic myoclonus in rodents
Generating mouse models of mitochondrial disease
Secion VII: Tics. Tics and Tourette Syndrome: Phenomenology
Genetics of Tourette syndrome
Neural circuit abnormalities in Tourette syndrome
Animal models of Tourette Syndrome and obsessive-compulsive disorder
Section VIII: Paroxysmal movement disorders. Paroxysmal Movement Disorders: Clinical and Genetic Features
Mouse models of PNKD
Glut1 deficiency (G1D)
Animal models of episodic ataxia type 1 (EA1)
Mouse models of episodic ataxia type 2. Section IX: Tauopathies. Tauopathies: Classification, Clinical Features, and Genetics
Drosophila models of tauopathy
Tauopathy mouse models
Tau protein: biology and pathobiology
Section X: Other Parkinsonian syndromes: NBIA, MSA, PD + spasticity, PD + dystonia. Clinical Phenomenology and genetics of other parkinsonian syndromes associated with either dystonia or spasticity
Animal models of multiple-system atrophy
Modeling PKAN in mice and flies
Mouse models of FA2H deficiency
Mouse models of neuroaxonal dystrophy caused by PLA2G6 gene mutations
Section XI: Ataxias. Genetics and Clinical Features of Inherited Ataxias
Animal models of spinocerebellar ataxia type 1
Mouse models of SCA3 and other polyglutamine repeat ataxias
animal models of Friedreich ataxia
Ataxia-telangiectasia and the biology of ataxia-telangiectasia mutated (ATM)
Autosomal recessive ataxias due to defects in DNA repair
Caenorhabditis elegans models to study the molecular biology of ataxias
Section XII: Hereditary spastic paraplegia. Hereditary Spastic Paraplegias: Genetics and Clinical Features
Mouse models of autosomal dominant spastic paraplegia
Murine models of autosomal recessive hereditary spastic paraplegia
Modeling hereditary spastic paraplegia (HSP) in zebrafish
Drosophila models of hereditary spastic paraplegia
Caenorhabditis elegans models of hereditary spastic paraplegia
Use of arabidopsis to model hereditary spastic paraplegia and other movement disorders
Section XIII: Restless legs syndrome. Clinical Phenotype and Genetics of Restless Legs Syndrome
Combined D3 receptor/iron-deficient mouse model
Use of Drosophila to study restless legs syndrome
The A11 lesion/iron deprivation animal model of restless legs syndrome
Btbd9 knockout mice as a model of restless legs syndrome.